Nootropic Peptides
Selank
10mg
Synthetic tuftsin analogue heptapeptide. Nootropic research compound.
99.751% purity · Third-party tested · Batch UKPL-1637 · View certificate
- Same-day dispatch before 2pm, Mon to Fri
- Add £44.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £24.99 |
| 3-4 | 5% | £23.74 |
| 5-9 | 8% | £22.99 |
| 10-50 | 12% | £21.99 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Selank?
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, built on the immune peptide tuftsin. It is studied in rats and in vitro for its effects on GABAergic gene expression and enkephalin breakdown. We sell Selank in 5mg and 10mg vials of white lyophilised powder.
Full description
Selank (TKPRPGP) has the formula C₃₃H₅₇N₁₁O₉, a molecular weight of 751.9 g/mol and CAS number 129954-34-3. Its first four residues are tuftsin, a tetrapeptide released from the Fc region of the immunoglobulin G heavy chain.
The C-terminal Pro-Gly-Pro was added to slow enzymatic breakdown, the same approach used in Semax. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.
Selank Research Applications
- Enkephalin breakdown: Selank inhibited enzymatic hydrolysis of enkephalin in blood plasma, more potently than bacitracin or puromycin (Zozulya et al., Bull Exp Biol Med, 2001).
- GABAergic genes: in rat frontal cortex it changed the expression of dozens of neurotransmission genes within hours (Volkova et al., Front Pharmacol, 2016).
- GABA-like profile: those changes correlated with the changes GABA itself produced, which the authors read as allosteric modulation of the GABAergic system.
Study details
Both papers come from Russian groups, as does nearly all Selank literature. The 2001 enzyme study measured enkephalin hydrolysis in human plasma samples. The 2016 study measured gene expression in rat frontal cortex. Independent replication outside Russia is limited.
Selank vs Semax
Both are heptapeptides ending in the same Pro-Gly-Pro tail. Selank (751.9 g/mol) carries tuftsin, Thr-Lys-Pro-Arg, from immunoglobulin G. Semax (813.9 g/mol) carries Met-Glu-His-Phe from ACTH(4-10). Semax papers centre on BDNF, trkB and brain ischaemia; Selank papers centre on GABAergic genes and enkephalin breakdown. Running them side by side controls for the shared stabilising tail.
Research Overview
Selank is a synthetic heptapeptide analogue of tuftsin, an endogenous immunomodulatory peptide derived from the Fc region of immunoglobulin G. Developed at the Institute of Molecular Genetics in Russia, Selank has been studied extensively for its anxiolytic properties, GABA system modulation, and effects on immune function. The compound is often researched alongside Semax, where Semax investigations concentrate on cognitive enhancement and BDNF modulation, Selank research focuses on anxiety reduction, stress response regulation, and GABAergic neurotransmission. Selank has been approved in Russia as a pharmaceutical treatment for generalised anxiety disorder. Research has examined its influence on serotonin and norepinephrine metabolism, its modulation of interleukin expression, and its effects on enkephalin degradation. The peptide's dual anxiolytic and immunomodulatory profile represents a unique pharmacological combination not commonly found in single-molecule compounds. Studies have documented its effects on the hypothalamic-pituitary-adrenal (HPA) axis and its ability to stabilise enkephalins in blood serum, contributing to its anxiolytic mechanism of action.
Selank is built on the same design principle as Semax. It is the tuftsin sequence Thr-Lys-Pro-Arg extended with a C-terminal Pro-Gly-Pro tail, giving TKPRPGP, and as with Semax that PGP extension exists to blunt aminopeptidase degradation rather than to add activity of its own. The two compounds come from the same institute and share a structural strategy, which is why they are so often studied as a pair.
Two mechanisms dominate the published work. The first is GABAergic: research reports altered expression of genes encoding GABA-A receptor subunits in rat brain, which is the usual explanation offered for the anxiolytic profile. The second is enkephalinergic, Selank having been reported to inhibit the degradation of enkephalins in blood plasma and thereby prolong their action. Effects on interleukin expression and on serotonin and noradrenaline metabolism are described across the same literature, and the immunomodulatory activity traces back to tuftsin's own role as an immunostimulatory fragment of immunoglobulin G.
The same evidential caveat applies as to Semax, and for the same reason. The literature is predominantly Russian-language, concentrated in a small institutional cluster, and thinly replicated independently. Selank is registered in Russia for generalised anxiety disorder but holds no marketing authorisation in the UK, the EU or the US.
Product Specifications
- Molecular Formula
- C₃₃H₅₇N₁₁O₉
- Molecular Weight
- 751.9 g/mol
- Sequence
- Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
- Purity
- 99.751% (RP-HPLC)
- Batch
- UKPL-1637
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Third-party tested
- Batch
- UKPL-1637
- Purity
- 99.751%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Lab
- Janoshik Analytical
- Tested
- Sep 2026
Original Janoshik report. Tap to enlarge.Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store sealed vials at -20°C, away from light and moisture, for up to 24 months. After reconstitution, keep the solution at 2-8°C and use it within 4 weeks. For longer storage, freeze single-use aliquots at -20°C and avoid repeated freeze-thaw cycles.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature and swab both stoppers with alcohol. Add the bacteriostatic water slowly down the inside wall of the vial, not onto the powder. Swirl gently until dissolved, without shaking. The solution should be clear and colourless.
- Maintain aseptic technique during handling. Sterilise vial stoppers with alcohol prior to needle insertion.
- Aliquot reconstituted peptide into single-use volumes to avoid degradation from repeated freeze-thaw cycles.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Inhibitory effect of Selank on enkephalin-degrading enzymes (Bull Exp Biol Med, 2001)
- Selank affects expression of genes involved in GABAergic neurotransmission (Front Pharmacol, 2016)
Published research on Selank is indexed on PubMed. See our full UK buyer's guide for Selank and UK buyer's guide for Selank 10mg.
Selank Price (UK)
Selank is for sale in 2 vial sizes, priced from £15.95 for 5mg to £24.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Selank 10mgThis page | £24.99 | £2.50Best value | In stock |
| Selank 5mg | £15.95 | £3.19 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is Selank used for in research?
Selank is primarily researched for its anxiolytic properties, GABA system modulation, and effects on stress and immune function. Research indicates it modulates GABAergic, serotonergic, and noradrenergic neurotransmitter systems and has been approved in Russia as a pharmaceutical treatment for generalised anxiety disorder.
Does Selank help with anxiety and stress in research?
Research indicates that Selank modulates several neurotransmitter systems including the GABAergic system (enhancing GABA-mediated inhibitory signalling), serotonergic pathways, and noradrenergic transmission. It has also been shown to stabilise enkephalins in blood serum, which contributes to its anxiolytic mechanism of action in research models.
What is the difference between Selank and Semax?
Both are synthetic heptapeptides developed in Russia, but they have different research focuses. Semax is derived from ACTH fragment 4-10 and is primarily studied for cognitive enhancement and BDNF modulation. Selank is an analogue of tuftsin and is primarily researched for anxiolytic properties, GABA modulation, and immune function effects.
What is in a Selank vial?
Each vial contains Selank lyophilised powder (freeze-dried for stability). Selank has a molecular weight of 863.0 g/mol with the molecular formula C₃₃H₅₇N₁₁O₉. This compound is supplied for research use only.
Where can I buy Selank in the UK?
You can buy Selank online from our UK stock in 5mg and 10mg vials, each with a published certificate. The 10mg batch carries a Janoshik Analytical report you can look up on their site; the 5mg batch is a supplier-reported analysis with independent verification pending. Orders placed before 2pm on a working day are dispatched the same day, and UK delivery is free over £69.
Is your Selank 10mg UK independently tested?
The 10mg batch is. It measured 99.751% purity by RP-HPLC at Janoshik Analytical, with 12.21mg measured content against the 10mg label claim. The 5mg vial is a separate batch carrying a supplier-reported certificate, with independent verification pending.
What is Selank peptide used for in research?
Selank peptide is used to study a stabilised form of tuftsin, the Thr-Lys-Pro-Arg fragment of immunoglobulin G. Current work centres on GABAergic gene expression and enkephalin-degrading enzymes.
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