DSIP
5mg
DSIP (Delta Sleep-Inducing Peptide) is a nine amino acid neuropeptide first identified in 1977 from cerebral venous blood during induced sleep studies. Research has examined its role in sleep regulation, stress modulation and neuroendocrine activity, including effects on circadian rhythm and interactions with the hypothalamic-pituitary axis. A compound of interest in sleep physiology and stress-response research. Supplied as lyophilised powder, third-party tested, lab certificate published on this page.
Published research on DSIP is indexed on PubMed. See our full UK buyer's guide for DSIP.
Intended Use: Strictly for in-vitro laboratory research. Not for use in humans or animals. Not to be used in foods, drugs, or medical diagnostics. This product has not been evaluated by the MHRA or FDA. Buyer assumes full responsibility for safe handling and regulatory compliance.
99.07%
Purity
LAB
Certified
SAME
Day Ship
Quantity
Add £31.01 more for free UK delivery
Damaged or lost? Free reshipment guaranteed
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
Research Use Only
This product is intended strictly for research and laboratory use only. Not for human consumption, medical use, or diagnostic purposes.
Certificate of Analysis
Third-party tested
Lyophilised Stability
24 months
Sealed at -20°C, light-protected
Reconstituted Stability
Up to 3 months
Stored at 2-8°C after mixing
Cold-Chain Shipping
Always
Dry-cold pack, Royal Mail Tracked 24
Important Notice
All compounds are sold individually and do not include research supplies. Products are provided in lyophilised (powder) form and require proper reconstitution before use in research settings.
Related Products
DSIP Price (UK)
DSIP 5mg is £13.99 per vial, supplied from stock in the UK with a third-party HPLC certificate published on this page. UK delivery is £4.50 by Royal Mail Tracked 24, or free once your basket reaches £45 (£31.01 away at this price). Orders placed before 2pm on a working day are dispatched the same day.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| DSIP 5mgThis page | £13.99 | £2.80 | In stock |
Prices are in GBP and shown per vial as supplied, lyophilised, for in-vitro laboratory research only. Cost per mg is given so researchers can compare vial sizes on a like-for-like basis. Stock and pricing on this table are read live from our inventory, so they match the basket. See our FAQ for delivery and payment options, and quality & testing for how each batch is verified.
Research Overview
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide consisting of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. First identified in 1977 from cerebral venous blood of rabbits during electrically induced sleep by Swiss researchers Schoenenberger and Monnier, DSIP has since been studied for its role in sleep architecture regulation, stress response modulation, and neuroendocrine activity. Research has examined DSIP's effects on circadian rhythm regulation, its interactions with the hypothalamic-pituitary axis, and its potential influence on cortisol and ACTH levels during stress responses. Studies have documented effects on delta wave sleep patterns, from which the peptide derives its name. DSIP research extends beyond sleep physiology into areas including opioid receptor modulation, withdrawal symptom attenuation, and free radical scavenging activity. The peptide's stability in serum and its ability to cross the blood-brain barrier make it a practical research tool in sleep physiology and chronobiology. Its effects on reducing corticotropin levels suggest involvement in stress-adaptive pathways, adding complexity to its pharmacological profile beyond simple sleep induction.
DSIP was isolated by Schoenenberger and Monnier, who reported recovering it from the cerebral venous blood of rabbits during electrically induced sleep and published the characterisation in 1977. The sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, an unusually acidic nonapeptide.
It is worth being direct about the state of the evidence, because DSIP is a compound where the name promises more than the literature delivers. No specific DSIP receptor has ever been identified, the original sleep-induction findings have proved difficult to replicate consistently, and its status as a genuine endogenous sleep factor remains contested nearly fifty years after its description. Much of the subsequent work has instead concerned effects some distance from sleep, including opioid withdrawal models, stress and corticotropin responses, and antioxidant activity.
That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims. DSIP is not an approved medicine in any jurisdiction and is supplied as lyophilised powder for in-vitro laboratory research only.
Product Specifications
Laboratory Handling
- Store lyophilised vials at -20°C. Reconstituted DSIP should be refrigerated at 2-8°C and used within 4 weeks.
- Reconstitute with bacteriostatic water using gentle swirling. Avoid shaking or vortexing the peptide solution.
- Handle under aseptic laboratory conditions using sterile equipment throughout reconstitution and aliquoting.
- Avoid repeated freeze-thaw cycles. Prepare measured aliquots from reconstituted stock for consistent experimental use.
Frequently Asked Questions
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid neuropeptide first identified in 1977 from cerebral venous blood during induced sleep studies. Research has examined its role in sleep architecture, stress response modulation, and neuroendocrine activity. Supplied as lyophilised powder for in-vitro research use only.
DSIP Research Applications
DSIP is studied in sleep physiology and chronobiology research, including delta-wave sleep architecture, hypothalamic-pituitary-axis interactions, cortisol and ACTH modulation, opioid receptor pathway research, and free-radical scavenging activity.
Reconstitution Guide
Allow vials to reach room temperature, then sterilise the rubber stopper of both the peptide vial and the bacteriostatic water vial with an alcohol swab. Slowly draw your bacteriostatic water into a sterile insulin syringe, then inject it gently down the inner glass wall of the peptide vial, never directly onto the lyophilised powder. Once added, gently swirl the vial in a slow circular motion until fully dissolved. Never shake or vortex. The solution should be clear and colourless. Label the vial with the reconstitution date and store immediately.
See our full peptide reconstitution guide and reconstitution calculator for step-by-step protocol.
Storage Instructions
Lyophilised vials should be stored at -20°C, protected from light and moisture, and remain stable for up to 24 months. Once reconstituted with bacteriostatic water, store the solution at 2-8°C (standard refrigerator) and use within approximately 3 months. For storage beyond that, prepare single-use aliquots at -20°C, where reconstituted peptide remains stable for up to 6 months. Avoid repeated freeze-thaw cycles and always handle under sterile laboratory conditions.
Frequently Asked Questions
Research Guides
DSIP
5mg · £13.99