Peptides
DSIP
5mg
Nonapeptide involved in sleep regulation and stress research.
96.999% purity · Third-party tested · Batch UKPL-4164 · View certificate
- Same-day dispatch before 2pm, Mon to Fri
- Add £55.05 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £13.95 |
| 3-4 | 5% | £13.25save £0.70 |
| 5-9 | 8% | £12.83save £1.12 |
| 10-50 | 12% | £12.28save £1.67 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is DSIP?
DSIP (delta sleep-inducing peptide, INN emideltide) is a nonapeptide first isolated from rabbits in 1977. It is studied in sleep, stress-hormone and circadian research. We supply it as lyophilised powder in 5mg and 10mg vials.
Full description
The sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE), with a free acid C-terminus. The formula is C₃₅H₄₈N₁₀O₁₅, the molecular weight 848.8 g/mol and the CAS number 62568-57-4. Schoenenberger and Monnier isolated it from rabbit cerebral venous blood and named it for the delta-wave EEG activity it produced (PNAS, 1977).
No DSIP gene, parent protein or receptor has been isolated, and its natural occurrence is still unclear. Kovalzon and Strekalova (J Neurochem, 2006) called it a still unresolved riddle.
DSIP Research Applications
- Sleep EEG: in a double-blind test in 58 rabbits, only synthetic DSIP, of nine related peptides, enhanced delta and spindle EEG patterns (Schoenenberger and Monnier, 1977).
- Species: Graf and Kastin (1984) reported mainly delta sleep in rabbits, rats and mice, a stronger REM effect in cats, and a U-shaped dose curve.
- Stress axis: DSIP inhibited CRF-induced ACTH release from rat anterior pituitary in vitro, most strongly at 10 nM. Basal ACTH did not change (Okajima and Hertting, 1986).
- Replication: Kovalzon and Strekalova (2006) call the sleep-factor case weak. Some synthetic DSIP analogues promoted slow-wave sleep in rabbits and rats, but DSIP itself did not.
Study details
Graf and Kastin (1984) also list effects on electrophysiological activity, brain neurotransmitter levels, locomotor patterns and the withdrawal of neuropharmacological drugs. Much of this literature is decades old and poorly replicated, so DSIP suits hypothesis testing and replication work.
DSIP vs Conventional Sleep-Pathway Peptides
Established sleep-regulating peptides have a known gene, a precursor protein and a receptor. DSIP has none of the three on record, and its structure matches no known peptide family (Kovalzon and Strekalova, 2006). DSIP-like immunoreactivity sits in hypothalamic neurosecretory nuclei that are not particularly relevant to sleep regulation. The authors propose that an undiscovered DSIP-like peptide accounts for at least part of that signal and of DSIP's reported activity.
Research Overview
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide consisting of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. First identified in 1977 from cerebral venous blood of rabbits during electrically induced sleep by Swiss researchers Schoenenberger and Monnier, DSIP has since been studied for its role in sleep architecture regulation, stress response modulation, and neuroendocrine activity. Research has examined DSIP's effects on circadian rhythm regulation, its interactions with the hypothalamic-pituitary axis, and its potential influence on cortisol and ACTH levels during stress responses. Studies have documented effects on delta wave sleep patterns, from which the peptide derives its name. DSIP research extends beyond sleep physiology into areas including opioid receptor modulation, withdrawal symptom attenuation, and free radical scavenging activity. The peptide's stability in serum and its ability to cross the blood-brain barrier make it a practical research tool in sleep physiology and chronobiology. Its effects on reducing corticotropin levels suggest involvement in stress-adaptive pathways, adding complexity to its pharmacological profile beyond simple sleep induction.
DSIP was isolated by Schoenenberger and Monnier, who reported recovering it from the cerebral venous blood of rabbits during electrically induced sleep and published the characterisation in 1977. The sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, an unusually acidic nonapeptide.
It is worth being direct about the state of the evidence, because DSIP is a compound where the name promises more than the literature delivers. No specific DSIP receptor has ever been identified, the original sleep-induction findings have proved difficult to replicate consistently, and its status as a genuine endogenous sleep factor remains contested nearly fifty years after its description. Much of the subsequent work has instead concerned effects some distance from sleep, including opioid withdrawal models, stress and corticotropin responses, and antioxidant activity.
That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims. DSIP is not an approved medicine in any jurisdiction and is supplied as lyophilised powder for in-vitro laboratory research only.
Product Specifications
- Molecular Formula
- C₃₅H₄₈N₁₀O₁₅
- Molecular Weight
- 848.8 g/mol
- Sequence
- Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
- Vial Content
- 5mg lyophilised peptide
- Purity
- 96.999% (RP-HPLC), below the ≥98.0% specification
- Batch
- UKPL-4164
- Form
- White lyophilised powder
Certificate of Analysis
Third-party tested
- Batch
- UKPL-4164
- Purity
- 96.999%
- Specification
- ≥98.0% (result below specification)
- Method
- RP-HPLC
- Lab
- Janoshik
- Tested
- Sep 2026
Original Janoshik report. Tap to enlarge.Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store DSIP powder at -20°C, away from light and moisture, for up to 24 months. After reconstitution, keep the solution at 2-8°C in a light-protected container and use it within 4 weeks. For longer storage, freeze single-use aliquots at -20°C and avoid repeated freeze-thaw cycles.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial and the bacteriostatic water reach room temperature and swab both stoppers with alcohol. Add the water slowly down the inside wall of the vial and swirl gently until dissolved. Do not shake. The N-terminal tryptophan is sensitive to light, so work away from direct sunlight. It also absorbs at 280 nm, which allows a UV check of concentration. The solution should be clear and colourless.
- Handle under aseptic laboratory conditions using sterile equipment throughout reconstitution and aliquoting.
- Avoid repeated freeze-thaw cycles. Prepare measured aliquots from reconstituted stock for consistent experimental use.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Nuclear changes in cultured human dystrophic muscle (Experientia, 1977)
- Moducren once versus twice daily in mild to moderate hypertension (Pharmatherapeutica, 1984)
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide (Schoenenberger and Monnier, Proc Natl Acad Sci U S A, 1977)
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle (Kovalzon and Strekalova, J Neurochem, 2006)
- Delta-sleep-inducing peptide (DSIP): a review (Graf and Kastin, Neurosci Biobehav Rev, 1984)
- DSIP inhibited CRF-induced ACTH secretion from rat anterior pituitary in vitro (Okajima and Hertting, Horm Metab Res, 1986)
Published research on DSIP is indexed on PubMed. See our full UK buyer's guide for DSIP and UK buyer's guide for DSIP 5mg.
DSIP Price (UK)
DSIP is for sale in 2 vial sizes, priced from £13.95 for 5mg to £27.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| DSIP 5mgThis page | £13.95 | £2.79Best value | In stock |
| DSIP 10mg | £27.99 | £2.80 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is the history of DSIP discovery?
DSIP was first identified in 1977 by Swiss researchers Schoenenberger and Monnier, who isolated it from cerebral venous blood of rabbits during electrically induced sleep. The peptide was named Delta Sleep-Inducing Peptide after its observed effects on promoting delta wave (slow-wave) sleep patterns in experimental models.
How does DSIP affect sleep architecture?
Research has shown that DSIP influences sleep architecture by promoting delta wave (slow-wave) sleep, the deepest stage of non-REM sleep associated with physical restoration and growth hormone secretion. Studies have also examined its effects on circadian rhythm regulation and its interactions with the hypothalamic-pituitary axis involved in sleep-wake cycle control.
What research areas beyond sleep involve DSIP?
Beyond sleep physiology, DSIP has been studied for its effects on stress response modulation (reducing corticotropin and cortisol levels), opioid receptor interactions, withdrawal symptom attenuation in substance dependence models, free radical scavenging and antioxidant activity, and neuroendocrine regulation through hypothalamic-pituitary axis interactions.
What is the molecular weight of DSIP?
DSIP has a molecular weight of 848.8 g/mol with the molecular formula C₃₅H₄₈N₁₀O₁₅. This nine-amino-acid neuropeptide has a molecular size that allows it to cross the blood-brain barrier and exert effects on sleep architecture and neuroendocrine regulation. This compound is supplied for research use only.
Where can I buy DSIP in the UK?
UK Peptide Lab sells DSIP in 5mg and 10mg vials from UK stock. Orders placed before 2pm (UK time) on a working day are dispatched the same day, and UK delivery is free over £69.
Is your DSIP 5mg UK third-party tested?
Yes. Batch UKPL-4164 was tested by Janoshik Analytical at 96.999% purity by HPLC, below the 98.0% specification printed on its certificate. The full certificate is published in the certificate section. The 10mg vial is a separate batch with its own certificate.
What is DSIP peptide used for in research?
Preclinical sleep, stress-hormone and circadian research: delta-wave EEG in rabbits and rodents, ACTH regulation in pituitary tissue, and locomotor rhythms.
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