Growth Hormone Secretagogues
Ipamorelin
5mg
Selective GH secretagogue and ghrelin receptor agonist pentapeptide.
99.971% purity · Third-party tested · Batch UKPL-6540 · View certificate
- Same-day dispatch before 2pm, Mon to Fri
- Add £49.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £19.99 |
| 3-4 | 5% | £18.99save £1.00 |
| 5-9 | 8% | £18.39save £1.60 |
| 10-50 | 12% | £17.59save £2.40 |
CJC-1295 + Ipamorelin 5+5mg
Pre-blended GHRH + GHRP research peptide vial. CJC-1295 (no DAC) and Ipamorelin combined.
All components in one lyophilised vial, with one certificate.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that acts at the ghrelin receptor, GHS-R1a. It is the standard selective agonist in GH-axis research. We supply it as lyophilised powder in 5mg and 10mg vials.
Full description
Ipamorelin, often shortened to Ipa, has the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Its formula is C₃₈H₄₉N₉O₅, its molecular weight 711.85 g/mol and its CAS number 170851-70-4. It carries two D-amino acids and a C-terminal amide.
Novo Nordisk developed it under the code NNC 26-0161. It came from a series of compounds lacking the central Ala-Trp dipeptide of GHRP-1 (Raun et al., Eur J Endocrinol, 1998).
Ipamorelin Research Applications
- Potency: an EC50 of 1.3 nmol/l for GH release in rat pituitary cells, against 2.2 nmol/l for GHRP-6 (Raun et al., 1998).
- Selectivity: in swine, ACTH and cortisol rose no more than with GHRH, even at over 200 times its GH ED50. FSH, LH, prolactin and TSH were unchanged.
- Bone growth: in adult female rats, longitudinal bone growth rose from 42 to 52 µm/day, with total IGF-I unchanged (Johansen et al., 1999).
- Bone mineral: 12 weeks raised bone mineral content in female rats through larger bones, not denser ones (Svensson et al., 2000).
Study details
It is the usual selective agonist control in GHS-R1a receptor studies. Two-receptor designs pair it with a GHRH analogue such as CJC-1295 or sermorelin.
Ipamorelin vs GHRP-2 and GHRP-6
All three act at GHS-R1a. GHRP-2 and GHRP-6 are hexapeptides; ipamorelin is a pentapeptide. In conscious swine, ipamorelin and GHRP-6 had similar GH potency, with ED50s of 2.3 and 3.9 nmol/kg. GHRP-2 was more potent but less efficacious. Only GHRP-2 and GHRP-6 raised ACTH and cortisol (Raun et al., 1998). Use ipamorelin to study GH release without HPA-axis activation, and the older GHRPs when that interplay is the endpoint.
Research Overview
Ipamorelin is a synthetic pentapeptide and highly selective growth hormone secretagogue (GHS). It acts by mimicking the endogenous hormone ghrelin and binding to the growth hormone secretagogue receptor type 1a (GHS-R1a) in the anterior pituitary gland. Ipamorelin is distinguished from other growth hormone releasing peptides (GHRPs) such as GHRP-2 and GHRP-6 by its exceptional selectivity, it stimulates growth hormone release without significantly elevating cortisol, prolactin, or adrenocorticotropic hormone (ACTH) levels. This selectivity makes Ipamorelin the most specific GHS available for endocrine research, minimising confounding hormonal variables in experimental designs. In current research practice, Ipamorelin is frequently studied in combination with CJC-1295 (modified GRF 1-29) for synergistic growth hormone secretion, Ipamorelin acting at the GHS receptor and CJC-1295 acting at the GHRH receptor to produce amplified pulsatile GH release through complementary receptor pathways.
The primary reference is Raun and colleagues (Eur J Endocrinol, 1998), the paper that introduced the molecule and established the property it is known for. They described it as the first growth hormone releasing peptide with a selectivity approaching that of GHRH itself, reporting growth hormone release without the accompanying ACTH and cortisol elevation characteristic of GHRP-6 and hexarelin. Structurally it is a pentapeptide with a C-terminal amide and two D-amino acids, both features contributing to protease resistance.
It was developed as a research compound under the code NNC 26-0161 and taken into a discontinued clinical study, so despite reaching human trials Ipamorelin holds no marketing authorisation in any jurisdiction. It is supplied here as a lyophilised research chemical for in-vitro laboratory use only.
Product Specifications
- Molecular Formula
- C₃₈H₄₉N₉O₅
- Molecular Weight
- 711.85 g/mol
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH₂
- Vial Content
- 5mg lyophilised peptide
- Purity
- 99.971% (RP-HPLC)
- Batch
- UKPL-6540
- Form
- White lyophilised powder
- CAS Number
- 170851-70-4
Certificate of Analysis
Third-party tested
- Batch
- UKPL-6540
- Purity
- 99.971%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Lab
- Janoshik Analytical
- Tested
- Sep 2026
Original Janoshik report. Tap to enlarge.Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store ipamorelin powder at -20°C, away from light and moisture, for up to 24 months. Once reconstituted it lasts up to 4 weeks in the fridge at 2-8°C. For longer storage, freeze single-use aliquots at -20°C and avoid repeated freeze-thaw cycles.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial and the bacteriostatic water reach room temperature and swab both stoppers with alcohol. Add the water slowly down the inside wall of the vial and swirl gently until dissolved. Do not shake. With no methionine, cysteine or tryptophan in the sequence, sterility is the main concern. The solution should be clear and colourless.
- Handle under aseptic conditions using sterile syringes. Wipe vial stopper with an alcohol swab before each use.
- Avoid repeated freeze-thaw cycles. Prepare single-use aliquots where possible to maintain peptide integrity.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Ipamorelin, the first selective growth hormone secretagogue (Raun et al., Eur J Endocrinol, 1998)
- Ipamorelin induces longitudinal bone growth in rats (Johansen et al., Growth Horm IGF Res, 1999)
- Ipamorelin and GHRP-6 increase bone mineral content in female rats (Svensson et al., J Endocrinol, 2000)
- Pharmacokinetics of ipamorelin and other GH secretagogues (Johansen et al., Xenobiotica, 1998)
- GH-releasing peptide and GHRH in normal men (Bowers et al., J Clin Endocrinol Metab, 1990)
- Ipamorelin in postoperative ileus, a phase 2 study (Beck et al., Int J Colorectal Dis, 2014)
Published research on Ipamorelin is indexed on PubMed. See our full UK buyer's guide for Research Peptides, UK buyer's guide for Ipamorelin, UK buyer's guide for Ipamorelin 5mg, UK buyer's guide for Ipamorelin CoA and UK buyer's guide for Peptide Price per mg.
Ipamorelin Price (UK)
Ipamorelin is for sale in 2 vial sizes, priced from £19.99 for 5mg to £29.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Ipamorelin 5mgThis page | £19.99 | £4.00 | In stock |
| Ipamorelin 10mg | £29.99 | £3.00Best value | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is Ipamorelin (Ipa) used for in research?
Ipamorelin (Ipa) is a selective growth hormone secretagogue, it stimulates GH release without significantly affecting cortisol, prolactin, or ACTH. This makes it one of the most specific GH research peptides available. It is frequently studied alongside CJC-1295 for synergistic growth hormone release.
Can Ipamorelin and CJC-1295 be used together?
Ipamorelin and CJC-1295 are frequently studied together for synergistic growth hormone release. They act through complementary receptor pathways, Ipamorelin binds the GHS-R1a (ghrelin receptor) while CJC-1295 binds the GHRH receptor. This dual-pathway activation produces amplified pulsatile GH secretion greater than either compound alone.
How does Ipamorelin differ from other GH peptides?
Unlike GHRP-2 and GHRP-6, which also stimulate cortisol, prolactin, and ACTH release, Ipamorelin specifically targets the GHS-R1a receptor to promote growth hormone secretion without significantly affecting other pituitary hormones. This selectivity makes it ideal for research where isolating GH effects is important.
What is in an Ipamorelin vial?
Each vial contains Ipamorelin lyophilised powder (freeze-dried for stability). Ipamorelin has a molecular weight of 711.9 g/mol with the molecular formula C₃₈H₄₉N₉O₅. This compound is supplied for research use only.
Where can I buy Ipamorelin in the UK?
You can buy ipamorelin peptide online from UK Peptide Lab, in 5mg and 10mg vials from UK stock. Orders placed before 2pm (UK time) on a working day are dispatched the same day. UK delivery is free over £69.
Is your Ipamorelin 5mg UK third-party tested?
Yes. Janoshik Analytical tested batch UKPL-6540 at 99.971% purity by RP-HPLC, against a 98.0% specification. Check the batch number on your vial against the published certificate.
What is Ipamorelin peptide used for in research?
GH-axis pharmacology: receptor studies, GH release in rats and swine, and rat bone growth. Ghrelin-receptor agonists also affect gut motility, so it reached a phase 2 trial in postoperative ileus. It showed no significant difference from placebo in time to a tolerated meal (Beck et al., 2014).
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