Growth Hormone Secretagogues
Ipamorelin
10mg
Ghrelin-receptor agonist pentapeptide, 10mg vial.
99.61% purity · Supplier-reported analysis · Batch UKPL-9516 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £39.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £29.99 |
| 3-4 | 5% | £28.49save £1.50 |
| 5-9 | 8% | £27.59save £2.40 |
| 10-50 | 12% | £26.39save £3.60 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with selective agonist activity at the ghrelin receptor. Research has examined its growth hormone secretagogue activity and its selectivity profile relative to other GHRP-class peptides. This 10mg presentation is the higher-mass research format of our 5mg vial.
Full description
Ipamorelin 10mg holds twice the lyophilised mass of our 5mg vial, in the same single-vial glass format. The compound is identical: the pentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, CAS 170851-70-4. It is a selective agonist at GHS-R1a, the ghrelin receptor. Raun and colleagues (Eur J Endocrinol, 1998) described it as the first selective growth hormone secretagogue. It came from a series of compounds that lack the central Ala-Trp dipeptide of GHRP-1.
Ipamorelin Research Applications
- Potency in vitro: in primary rat pituitary cells ipamorelin released GH with an EC50 of 1.3 nmol/l and an Emax of 85%. GHRP-6 gave 2.2 nmol/l and 100% (Raun et al., 1998).
- Selectivity: in swine it did not raise ACTH or cortisol even at more than 200 times the ED50 for GH release (Raun et al., Eur J Endocrinol, 1998). FSH, LH, PRL and TSH were unaffected.
- Bone growth: Johansen and colleagues (Growth Horm IGF Res, 1999) reported faster longitudinal bone growth in adult female rats, from 42 to as much as 52 µm/day. Total IGF-I did not change.
- Kinetics: Gobburu and colleagues (Pharm Res, 1999) built a pharmacokinetic-pharmacodynamic model of ipamorelin and the GH response.
Study details
Typical designs use ipamorelin as the selective agonist control in GHS-R1a binding or calcium-mobilisation assays in transfected cell lines. Others study pulsatile GH release or bone metabolism, or pair it with a GHRH-receptor agonist such as CJC-1295. The 10mg vial suits concentration-response matrices, long time-course work and analytical method development. Running the whole design on one batch keeps a single purity figure and certificate behind the dataset.
The 10mg Vial vs the 5mg Vial: Content, Cost and Working Life
Both vials hold the same peptide, so the choice is about logistics. At a fixed fill volume the 10mg vial reaches twice the concentration, so scale the water to the concentration your protocol needs. Cost per milligram falls with vial size, because vial, stopper, freeze-drying and testing costs are paid per vial. One batch and one certificate also cover twice as much work. Ipamorelin has no methionine, cysteine or tryptophan, so a longer in-use window carries less oxidation risk than for many peptides. What does grow is the number of stopper punctures and the working life of one stock, which aliquoting at reconstitution handles.
Research Overview
This page covers the 10mg presentation. The compound is the same synthetic pentapeptide supplied in the standard vial, sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, CAS 170851-70-4, a selective agonist at the ghrelin receptor GHS-R1a. Its characterisation by Raun and colleagues (Eur J Endocrinol, 1998) as the first selective growth hormone secretagogue, and the receptor context established by Howard and colleagues (Science, 1996) and Kojima and colleagues (Nature, 1999), are documented in full on the main Ipamorelin page. What is specific to the 10mg vial is handling and economics.
Ten milligrams is twice the content of the 5mg vial in the same single-vial glass format, so at a fixed fill volume the reconstituted stock is twice as concentrated. Fill volume must therefore be scaled to the target concentration rather than carried over from smaller-vial work, and the resulting concentration recorded against the batch. Unlike methionine-bearing peptides in the secretagogue class, ipamorelin carries no methionine, no cysteine and no tryptophan, and its D-amino acid and aminoisobutyric acid residues give the molecule marked stability in solution, so oxidative exposure is not the governing constraint on a larger vial. The constraints that do grow with vial size are microbial and mechanical: a vial holding twice the mass is typically accessed over a longer period and across more stopper penetrations, so sterility discipline and aliquoting into single-use volumes matter more here than on a 5mg vial.
The offsetting advantages are batch continuity under one certificate of analysis and a lower cost per milligram, since vial, stopper, lyophilisation and assay costs are incurred per vial rather than per milligram. Each vial contains 10mg of ipamorelin as white lyophilised powder, batch UKPL-9516, supplier-tested at 99.61% purity by HPLC, with the supplier certificate of analysis published on this page and independent third-party verification pending. Supplied strictly for in-vitro laboratory research use only.
Product Specifications
- Molecular Formula
- C₃₈H₄₉N₉O₅
- Molecular Weight
- 711.85 g/mol
- CAS Number
- 170851-70-4
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH₂
- Vial Content
- 10mg lyophilised peptide
- Purity
- 99.61% (HPLC, supplier-tested)
- Batch
- UKPL-9516
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9516
- Purity
- 99.61%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store the sealed powder at -20°C, away from light and moisture. Reconstituted ipamorelin keeps for up to 4 weeks in the fridge at 2-8°C. On a 10mg vial the risks are repeated stopper punctures and freeze-thaw of one long-lived stock, not air exposure. Aliquot at reconstitution, freeze the aliquots, and thaw each one once.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial and the bacteriostatic water reach room temperature, then swab both stoppers with alcohol. Add the water slowly down the inside wall of the vial, not onto the powder, and swirl gently until dissolved. Do not shake or vortex. The solution should be clear and colourless. Label the vial with the reconstitution date and the concentration.
- Scale the bacteriostatic water fill volume to your target concentration. A 10mg vial reaches twice the concentration of a 5mg vial at the same fill volume, so a volume carried across from smaller-vial work will not reproduce the same stock.
- The sequence contains no methionine, cysteine or tryptophan, and the D-amino acid and aminoisobutyric acid residues make ipamorelin comparatively resilient in solution, so no oxidation-specific handling is required. Sterility is the limiting factor.
- Aliquot into single-use volumes immediately after reconstitution and hold them at -20°C. A 10mg vial means a longer in-use window and more accumulated stopper penetrations on a single stock, and aliquoting isolates each withdrawal from that history.
- Introduce the diluent slowly down the inner glass wall, never onto the lyophilised cake, and swirl gently until fully dissolved. Allow the vial to reach room temperature before opening.
- Do not leave dilute solution standing at room temperature. Return aliquots to cold storage promptly after each withdrawal rather than working from a stock left out across a session, and avoid repeated freeze-thaw cycles.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Ipamorelin, the first selective growth hormone secretagogue (Eur J Endocrinol, 1998)
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats (Growth Horm IGF Res, 1999)
- Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers (Pharm Res, 1999)
Published research on Ipamorelin is indexed on PubMed. See our full UK buyer's guide for Ipamorelin 10mg, UK buyer's guide for Ipamorelin CoA and UK buyer's guide for Peptide Price per mg.
Ipamorelin Price (UK)
Ipamorelin is for sale in 2 vial sizes, priced from £19.99 for 5mg to £29.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Ipamorelin 5mg | £19.99 | £4.00 | In stock |
| Ipamorelin 10mgThis page | £29.99 | £3.00Best value | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is in an Ipamorelin 10mg vial?
An Ipamorelin 10mg vial contains 10 milligrams of the pentapeptide as a white lyophilised powder, twice the content of the 5mg vial. Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular weight 711.85 g/mol, CAS 170851-70-4. Batch UKPL-9516 is supplier-tested at 99.61% purity by HPLC with a quantity assay confirming the 10mg content, the supplier certificate of analysis is published on this page, and independent third-party verification is pending.
How does the Ipamorelin 10mg vial differ from the 5mg vial?
Only in the mass of peptide per vial. It is the same compound, the same sequence and the same lyophilised powder, at twice the content. The practical differences are that a 10mg vial reaches twice the concentration at a given reconstitution volume, that all 10mg shares one in-use window and one reconstitution date once opened, and that a single batch and certificate of analysis covers twice as much work. Each size carries its own batch and its own published certificate.
Does a 10mg vial of ipamorelin need special handling?
Not for oxidation, which is the usual concern with larger vials of methionine-bearing peptides. Ipamorelin has no methionine, cysteine or tryptophan, and its non-natural residues give it stability in solution, so the constraints on a 10mg vial are sterility and mechanical wear: a longer working life and more stopper penetrations on one stock. Draw single-use aliquots at the point of reconstitution and hold them at -20°C.
How much bacteriostatic water does an Ipamorelin 10mg vial need?
That depends entirely on the concentration your protocol specifies, so there is no fixed figure and we do not provide dosing information. The arithmetic is mass divided by volume: 10mg reconstituted with 2mL gives a 5mg/mL stock, and the same 10mg in 1mL gives 10mg/mL. Because a 10mg vial reaches twice the concentration of a 5mg vial at identical fill volume, volumes should not be carried over unchanged between the two sizes.
Is the 10mg vial the same compound as the 5mg vial?
Yes. Both vials contain the identical pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH₂, at 711.85 g/mol, CAS 170851-70-4, and neither is a modified analogue or a different sequence. The 10mg vial is not a stronger material, it simply holds more of it. Each vial size carries its own batch number and its own published certificate of analysis, so the purity figure quoted for the 10mg vial applies to that batch specifically rather than being inherited from the 5mg batch.
What purity is your Ipamorelin 10mg and is it supplier-tested?
The current Ipamorelin 10mg batch is UKPL-9516, supplier-tested at 99.61% purity by HPLC, and the supplier certificate of analysis is published on this product page rather than provided on request, with independent third-party verification pending. Check that the batch number on the vial matches the certificate, and that the report carries a quantity assay confirming 10mg of content, since purity alone says nothing about how much peptide is actually in the vial.
Where can I buy Ipamorelin 10mg in the UK?
UK Peptide Lab supplies Ipamorelin 10mg in the UK at £29.99, batch UKPL-9516, supplier-tested with the certificate of analysis published on this page and independent third-party verification pending, and dispatched the same day on orders placed before 3pm UK time. Free UK Royal Mail Tracked shipping on orders over £69. The 5mg vial of the same compound is also stocked. Purchasers must be 18 or over and confirm research-only use. Not for human consumption or any therapeutic application.
What purity is the Ipamorelin 10mg vial?
99.61% by HPLC for the current batch, UKPL-9516, on the supplier's analysis. The same certificate reports 10.04mg measured content against the 10mg label. Independent third-party verification is pending. The 5mg vial is a separate batch with its own certificate, so this figure applies to the 10mg batch only.
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