Research Guides

Pinealon (EDR): Tripeptide Bioregulator Research Guide

By UK Peptide Lab Research Team•13 November 2026•6 min read

Key Takeaways

  • Pinealon is the tripeptide Glu-Asp-Arg (EDR), molecular weight 418.41 g/mol.
  • It belongs to the short-peptide bioregulator class described by Khavinson and colleagues.
  • The evidence base is largely preclinical and concentrated in one research group; independent replication is limited.
  • Supplied for in-vitro laboratory research only. No dosing information and no human-use claims.

What is Pinealon?

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (EDR) and a molecular weight of 418.41 g/mol. It belongs to the short-peptide bioregulator class described by Khavinson and colleagues, a body of work proposing that very short peptides can interact with DNA and histone proteins and so influence gene expression. UK Peptide Lab supplies Pinealon 10mg as lyophilised powder for in-vitro laboratory research use only.

The Proposed Mechanism

The central idea is that a peptide of only three residues is small enough to enter cells and reach the nucleus. A 2020 review in Molecules (PubMed 33396470) sets out how the EDR peptide might regulate gene expression and protein synthesis, framed around neurodegeneration models. A 2019 physical chemistry study (PubMed 30762356) examined how mono- and divalent ions affect Glu-Asp-Arg binding to DNA, which is the kind of binding-level question that has to be answered before any gene-regulation claim can be tested. These are proposals and in-vitro or modelling results. They do not establish an effect in people, and this guide makes no such claim.

How to Weigh the Evidence

Most published Pinealon and EDR work originates from a single research group, and much of it appeared in Russian-language journals. Independent replication is limited. A careful reader should separate three layers: what has been measured (binding, cell and animal data), what has been inferred (gene-regulation mechanisms), and what has not been tested (human outcomes). Only the first layer has direct support in the literature cited here.

Laboratory Handling

Pinealon is supplied as lyophilised powder. Store sealed at -20°C before reconstitution and away from light. Reconstitute with bacteriostatic water and follow your laboratory protocol for concentration; the peptide calculator performs the arithmetic. Avoid repeated freeze-thaw cycles. See the peptide storage guide for general handling.

Sourcing in the UK

Each batch of Pinealon 10mg carries its own certificate of analysis, linked on the product page. Orders placed before 3pm UK time are dispatched the same working day by Royal Mail Tracked 24. For in-vitro laboratory research use only, not for human or veterinary use.

Related Products

Pinealon 10mg Bacteriostatic Water

Disclaimer: This article is for research and educational purposes only. All information provided is not intended as medical advice. UK Peptide Lab products are not for human consumption and are sold strictly for laboratory research use only.

Frequently Asked Questions

What is Pinealon?

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg, abbreviated EDR, and a molecular weight of 418.41 g/mol. It is studied as a short-peptide bioregulator. It is supplied as lyophilised powder for in-vitro laboratory research only.

How strong is the evidence for Pinealon?

Published work is largely preclinical and comes predominantly from one research group, with limited independent replication. Treat mechanistic proposals as hypotheses, not settled findings.

Where can I buy Pinealon in the UK?

UK Peptide Lab lists Pinealon 10mg as a research compound with a batch-specific certificate of analysis on the product page and same-day dispatch on orders placed before 3pm UK time. Research use only.

References

  1. [1] EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Neurodegenerative Diseases. Molecules (2020). View →
  2. [2] Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction. J Phys Chem B (2019). View →

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